Harvard College

Olivier F Henry

Donald Elliot Ingber

Andy H Levine

Kevin Kit Parker

James Niemi

Anna Herland

Premananda Pai Indic

John Paul Osborne

Daniel Leo Miranda

Joseph Mooney

Huy Lam

Mustafa Karabas

Ben M Maoz

Alan Dunne

Benjamin Matthews

Christoph Matthias Kanzler

An organ-on-chip device for monitoring a biological function and including a membrane layer located at an interface region between a top microchannel and the a microchannel. The membrane includes a first type of cells forming a barrier between the top microchannel and the bottom microchannel. The device further includes a top layer having a first plurality of transendothelial electrical resistance (TEER) measurement electrodes for enabling direct monitoring of cell function and electrical activity of the first type of cells on the membrane. The device also has a multi-electrode array (MEA) layer with a second plurality of TEER measurement electrodes for enabling direct monitoring of cell function and electrical activity of a second type of cells on the MEA layer.

Integrated multi-electrode array and trans-endothelial electrical resistance in organ-on-a-chip microsystems

A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.

Systems and methods for monitoring, managing, and treating asthma and anaphylaxis

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Brookline, MA, United States of America

Olivier F Henry