Pact Pharma, Inc.

Adoc Ssf, LLC

Olivier Dalmas

Songming Peng

Barbara Sennino

Alex Franzusoff

Stefanie Mandl-Cashman

Xiaoyan Robert Bao

Zheng Pan

Duo An

Michael Bethune

Boi Bryant Quach

Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.

Compositions and methods for identification of antigen specific T cells

Disclosed herein are antigenic peptide-MHC molecules, termed comPACTs, and methods of producing such molecules. Also disclosed herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells.

Peptide-MHC compacts

Growing community of inventors

San Carlos, CA, United States of America

Olivier Dalmas