Actelion Pharmaceuticals Ltd

Idorsia Pharmaceuticals Ltd

Olivier Bezencon

Thomas Weller

Daniel Bur

Sylvia Richard-Bildstein

Lubos Remen

Thierry Sifferlen

Walter Fischli

Olivier Corminboeuf

Corinna Grisostomi

Bibia Heidmann

Romain Siegrist

John Gatfield

Simon Stamm

Christoph Boss

Michel Therien

Daniel Dube

John Scheigetz

Dwight MacDonald

Dan McKay

Austin Chih-Yu Chen

Walter Fiśchli

David Powell

Hans-Peter Weber

Sylvia Richard

The invention relates to compounds of formula (I) 

Triazole compounds as T-type calcium channel blockers

The invention relates to compounds of formula (I) wherein X, Y, R, R, (R), and (R)are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

Pyrazole compounds and their use as T-type calcium channel blockers

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. 

Bicyclononene derivatives

The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

Secondary amines as renin inhibitors

The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative of formula (I), enantiomers thereof, and their use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing at least one compound of formula (I): or (I'): and especially their use as inhibitors of renin.

Diazabicyclononene derivatives and use thereof

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.

Piperidine carboxylic acid amide derivatives

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin. 

7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases

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Allschwil, Switzerland

Olivier Bezencon