Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

Université Pierre Et Marie Curie (paris 6)

Institut Gustave Roussy

Inria Institut National De Recherche En Informatique Et En Automatique

Centre Henri Becquerel

Centre National De La Recherche Scientifique

Université Paris Descartes

Université Paris—sud

Université Pierre Et Marie Curie

Université Paris-sud 11

Ecole Centrale Paris

Sorbonne Université

Centre National De La Recherche Scientifique-cnrs

Centralesupelec

Olivier Bernard

William Vainchenker

Christian Bastard

Michaela Fontenay

Francois Delhommeau

Éric Pruvost

Franck Viguie

Antoine Sciandra

Hubert Bonnefond

Francis Mairet

Charlotte Combe

Filipa Lopes

Ghjuvan Grimaud

François Delhommeau

The invention relates to a bioreactor including: a light source (); a light sensor () facing said light source; a vat () that is placed between the light source () and the light sensor (), said vat being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms; a controller () connected to the light sensor () in order to control the vat () to obtain a chosen cellular-culture concentration (xi) in the culture medium during a working period, said light source () being capable of emitting incident light (L) of an input light intensity (Iin) in the direction of the vat (), and the light sensor () being capable of measuring an output light intensity (Iout) and of transmitting data relating to this intensity (Iout) to the controller for the control of the vat; and a system () for controlling the light source (), this system being arranged to adjust, during a period shorter than or equal to said working period, the input light intensity (Iin) to a setpoint value allowing a cellular stress to be induced in certain at least of said photosynthetic microorganisms.

Selective bioreactor for microalgae

The invention relates to a bioreactor comprising a tank () capable of being operated for a working period, said tank () being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source () arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe () for measuring the temperature of said culture medium in the tank, and a temperature regulator () capable of raising and lowering the temperature of said culture medium in the tank, and further comprising a control () of the temperature regulator arranged to adjust the temperature of the culture medium to a low setpoint value (VCB) during a first period, and to adjust the temperature of the culture medium to a high setpoint value (VCH) during a second period, the succession of said first and second periods making it possible to induce a cellular stress in at least some of said photosynthetic microorganisms during the working period.

Bioreactor for the selection of microalgae

The present invention concerns an in vitro method for diagnosing a myeloid tumour or a lymphoid tumour in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO: 2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumour or a lymphoid tumour.

TET2 as a diagnostic and pronostic marker in hematopoietic neoplasms

The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.

Bioreactor for microalgae

TET2 as a diagnostic and prognostic marker in hematopoietic neoplasms

The invention relates to a method for producing microalgae on a support () that is movably mounted essentially in an aqueous medium contained in a tank (), said method comprising a succession of phases in which the microalgae developing on the support () are exposed to sunlight and phases in the shade, the light intensity received in the shade being less than 50% of the average light intensity received during the sunlight exposure phases. The total length of the shade phases is more than 50% longer than the total length of the sunlight exposure phases.

Method and unit for producing microalgae

The present invention concerns an in vitro method for diagnosing a myeloid tumor or a lymphoid tumor in a subject, which comprises the step of analyzing a biological sample from said subject by (i) detecting the presence of a mutation in the Ten Eleven Translocation protein family member 2 gene (TET2) coding for the polypeptide having the sequence SEQ ID NO:2, and/or (ii) analyzing the expression of the TET2 gene; wherein the detection of such a TET2 mutation, of the absence of expression of TET2 or of the expression of a truncated TET2 is indicative of a subject developing or predisposed to develop a myeloid tumor or a lymphoid tumor.

TET2 as a new diagnostic and pronostic marker in hematopoietic neoplasms

Growing community of inventors

Vanves, France

Olivier Bernard