Bayer Schering Pharma Ag

Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Oliver Von Ahsen

Duy Nguyen

Arne Von Bonin

Anne Mengel

Gerhard Siemeister

Hans Briem

Ulrich Lücking

Rolf Jautelat

Beatrix Stelte-Ludwig

Hartmut Schirok

Ulrich Bothe

Ingo Hartung

Georg Kettschau

Olaf Prien

Uwe Gritzan

Ernst Weber

Sandra Berndt

Christian Votsmeier

Mark Trautwein

Ulrich Luecking

Ulf Boemer

Martin Krüger

Nikolaus Pawlowski

Katharina Filarsky

Sabine Hoff

Matyas Gorjanacz

Martina Schaefer

Philipp Ellinger

Patrick Jones

Helge Roider

Wiebke Maria Nadler

Su-Yi Tseng

Wolf-Dietrich Doecke

Michael Haerter

Krolikiewicz Konrad

Christian Bertling

Pascale Buchmann

Pedro Paz

Phaik Lyn Oh

The present invention relates to tools and methods for the generation of antibodies which specifically bind chemokine receptors, such as CC or CXC chemokine receptors. Provided are isolated sulfated polypeptides and conjugates thereof, which can be used for example as antigens or for off target panning to facilitate the generation of anti-human, anti-, and/or anti-mouse chemokine receptor antibodies, e.g. for the generation of antibodies with fully human CDRs and/or other favorable properties for therapeutic use. The present invention furthermore relates to antibodies and conjugates thereof which can be obtained by applying the aforementioned tools and methods. Provided are antibodies specifically binding to human,and/or murine CCR8 with favorable properties for therapeutic use, such as cross-reactive antibodies, fully human antibodies, low internalizing (including non-internalizing) antibodies, and antibodies efficiently inducing ADCC and/or ADCP in Treg cells.

Methods of treatment using CCR8 antibodies

The invention relates to sulphimides as protein kinase inhibitors of the general formula I 

Sulphimides as protein kinase inhibitors

The present invention relates to sulphoximine-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases. 

Sulphoximine-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments

The invention relates to sulfoximine-substituted pyrimidines of the general formula I processes for the preparation thereof and their use as drugs.

Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs

Growing community of inventors

Berlin, Germany

Oliver Von Ahsen