Merck Patent Gmbh

Oliver Poeschke

Dieter Dorsch

Guenter Hoelzemann

Norbert Beier

Kai Schiemann

Hans-Peter Buchstaller

Rolf Gericke

Markus Klein

Wolfgang Staehle

Christine G Charon

Ansgar Wegener

Michael Busch

Lars Thore Burgdorf

Christina Esdar

Ulrich Emde

Bjoern Hock

Sophie Hallakou-Bozec

Jeyaprakashnarayanan Seenisamy

Florian Lang

Dirk Wienke

Christa Burger

Michel Calderini

Helga Drosdat

Christine Charon

Compounds of the formula I in which X, Y, Q, M, Qand B have the meanings indicated in Claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Macrocycles as kinase inhibitors

Compounds of the formula I in which Rand Rhave the meanings indicated in claim, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Triazolo[4,5-d]pyrimidine derivatives

Compounds of the formula I in which X, Rand Rhave the meanings indicated in Claimare inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

Imidazopyrimidine derivatives

The invention provides novel substituted benzyl piperidine compounds according to Formula (I) as lysophosphatidic acid (LPA) receptor antagonists, their manufacture and use for the treatment of proliferative or inflammatory diseases, such as cancer, fibrosis or arthritis.

Benzyl piperidine compounds as lysophosphatidic acid (LPA) receptor antagonist

A variety of specific compounds within the scope of formula I which are useful as PI3K inhibitors and can be employed for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumours, and pharmaceutical compositions and kits containing said specific compounds.

Quinoxalines derivatives and pharmaceutical compositions and kits

The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: Rand Rindependently of one another represent H, OH, OA, OAc or methyl; R, R, R, R, R, R, Rand Rindependently of one another represent H, OH, OA, OAc, OCF, Hal, NO, CF, A, CN, OSOCH, SOCH, NH, or COOH; Rrepresents H or CH; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH, CHCH, OCHor &#x2014;CH(OH)&#x2014; and Hal represents F, Cl, Br or I. 

Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction

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Wiesbaden, Germany

Oliver Poeschke