Atriva Therapeutics Gmbh

Activaero Gmbh

Universitat Hamburg

Ventaleon Gmbh

Stephan Ludwig

Oliver Planz

Stephan Pleschka

Hans-Harald Sedlacek

Gerhard Scheuch

Michael Schindler

Sascha Rohn

Peer Riehle

Carmen Hartmayer

Julia Koch-heier

Helen Elisa Hoffmann

The present invention relates to PD-0184264 for use in a method for the treatment of a viral infection or a viral and bacterial coinfection. Also provided are compositions comprising such inhibitors for use in the treatment of a virus infection and the prevention and/or treatment of a bacterial co-infection.

MEK-inhibitor for the treatment of viral and bacterial infections

The present invention relates to PD-0184264 for use in a method for the prophylaxis and/or treatment of a co-infection comprising a bacterial infection and an influenza vims infection or a viral or bacterial infection alone. Also provided are compositions comprising such inhibitors for use in the prophylaxis and/or treatment of a co-infection comprising a bacterial infection and an influenza virus infection or a bacterial or viral infection alone.

The present invention relates to MEK inhibitors that are capable of displaying one or more beneficial therapeutic effects. The MEK inhibitors can be used in the prevention and/or treatment of viral infection. MEK inhibitors in combination with neuraminidase inhibitor compounds are capable of displaying one or more beneficial therapeutic effects in the treatment of viral diseases.

MEK inhibitors in the treatment of virus diseases

The invention relates to the use preferably of at least one active ingredient for the prophylaxis or therapy of a viral disease, wherein this active ingredient inhibits at least one component of the cellular signal transduction pathway for the activation of the transcription factor NF-kB such that virus multiplication is inhibited. The present invention relates furthermore to the local, preferably aerogenic, administration of the active ingredient according to the invention for inhibiting virus multiplication. The active ingredient according to the invention may be combined with at least one further antivirally effective substance for the prophylaxis or therapy of a viral disease.

Compositions and methods for the prophylaxis or treatment of viral diseases

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Rottenburg, Germany

Oliver Planz