King's College London

Gammadelta Therapeutics Ltd

Cancer Research Technology Limited

The Francis Crick Institute Limited

Oliver Nussbaumer

Adrian Hayday

Mihriban Tuna

Richard Woolf

Natalie Mount

Maria Luisa Iannitto

Richard Esmond Beatson

Mark Uden

Raj Mehta

Iva Zlatareva

Robin John Campbell Dart

Adam Laing

Joshua Freedman

Shristi Bhandari

Andrew Hutton

Oxana Polyakova

Daisy Melandri

Richard Beatson

Samuel Florence

Louisa Mathias

Pierre Vantourout

Kalle Soderstrom

Shefali Bhumbra

Robert Good

Raj Jaysukhlal Mehta

The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., a part of an adoptive T cell therapy).

Expansion of γδ T cells, compositions, and methods of use thereof

The present invention relates to a method for the isolation of lymphocytes (in particular γδ T cells) from a non-haematopoietic tissue sample comprising the steps of culturing a non-haematopoietic tissue sample which is an intact biopsy obtained from a non-haematopoietic tissue in the presence of Interleukin-2 (IL-2) and Interleukin-15 (IL-15); and collecting a population of lymphocytes cultured from the non-haematopoietic tissue sample. Methods of subsequent expansion are provided, as well as populations of isolated cells obtained by the method and uses thereof.

Methods for isolating and expanding cells

Protein constructs comprising a BTNL3/8 targeting moiety, a payload and an optional linker are described herein. Pharmaceutical compositions comprising the constructs, and methods of use thereof are presented.

BTNL3/8 targeting constructs for delivery of payloads

The present invention provides methods of expanding &#x3b3;&#x3b4; T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded &#x3b3;&#x3b4; T cells and methods of using the expanded &#x3b3;&#x3b4; T cells (e.g., apart of an adoptive T cell therapy).

Expansion of &#x3b3;&#x3b4; T cells, compositions, and methods of use thereof

This invention relates to the expansion of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident &#x3b3;&#x3b4; T cells and uses thereof.

Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells

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London, United Kingdom

Oliver Nussbaumer