Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim International Gmbh

Neurosearch A/s

Boehringer Ingelheim Pharma Kg

Oliver Meyer

Helmut Heitger

Norbert Hauel

Rolf Dach

Ingo Heddesheimer

Richard Ehlenz

Markus Sauter

Georg Zerban

Hartmut Schmidt

Sascha Wagner

Mark Goehlich

Mark Göhlich

A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1'-methylbenzimidazol-2&#x2032;-yl)benzimidazole with a compound of formula (IV) wherein Z is a leaving group, to obtain the compound 2-cyano-4&#x2032;-[2&#x2033;-n-propyl-4&#x2033;-methyl-6&#x2033;-(1&#x2032;&#x2033;-methylbenzimidazol-2&#x2032;&#x2033;-yl)benzimidazol-1&#x2033;-ylmethyl]biphenyl, and subsequently hydrolyzing the nitrile function to obtain the acid function.

Process for manufacture of telmisartan

The invention relates to a process for preparing 1,7'-dimethyl-2&#x2032;-propyl-2,5&#x2032;-bi-1H-benzimidazole of formula (I) 

Preparation of 1,7'-dimethyl-2&#x2032;-propyl-2,5&#x2032;-bi-1H-benzimidazole

The present invention relates to a process for preparing a 2-(ethoxymethyl)-tropane derivative or a pharmaceutically acceptable salt thereof, by reacting the corresponding 2-(hydroxymethyl)-tropane derivative with ethyl bromide in the presence of a base, and a phase transfer catalyst.

Process for the preparation of 2-(ethoxymethyl)-tropane derivatives

The invention provides a process for making compounds of the general formula I: wherein R, R, R, Rand Q are defined as in claim. The compounds of the general formula I are effective inhibitors of HIV reverse transcriptase.

Process for making a non-nucleoside HIV-1 reverse transcriptase inhibitor

The invention relates to a continuous process for preparing dihydropyrones of general formula I, wherein the groups Rand Rhave the meanings described herein.

Continuous process for preparing dihydropyrones

The present invention relates to an improved process for preparing 4-(6-bromohexyloxy)-butylbenzene by reacting 4-phenylbutanol with 1,6-dibromohexane in the presence of a base and a phase transfer catalyst, wherein 4-phenylbutanol in a diluent is metered into a mixture consisting of 1,6-dibromohexane, a base, a phase transfer catalyst and a diluent, and the use of the 4-(6-bromohexyloxy)-butylbenzene thus prepared for producing salmeterol in a method known per se.

Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene

Process for preparing vanillylamine or one of the salts thereof by reacting vanillin with hydroxylamine or the salts thereof in the presence of an organic salt, which may optionally be produced in situ, wherein the reaction is carried out in an inorganic or organic acid as diluent, and subsequently hydrogenating the resulting vanillyloxime with hydrogen in the presence of a suitable catalyst and an organic and/or inorganic acid.

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Dorsheim, Germany

Oliver Meyer