Roche Diagnostics Operations, Inc.

Other

Hitachi-High-Technologies Corporation

Hitachi High-Tech Corporation

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Oliver Larbolette

Hans-Peter Josel

Yukinori Sakashita

Taku Sakazume

Yoshihiro Yamashita

Katsuaki Takahashi

Herbert Andres

Stefan Quint

Shinya Matsuoka

Michihiro Saito

Michaela Windfuhr

Ralf Kraus

Friedrich Staebler

Guenter Ziegler

Rolf Herb

Kenichi Takahashi

The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

Branched-chain amines in electrochemiluminescence detection

An electrochemiluminescence method of detecting an analyte in a liquid sample and a corresponding analysis system. An analyte in a liquid sample is detected by first providing a receptacle containing a fluid comprising protein coated magnetic microparticles to a stirring unit. Stirring of the fluid is necessary since the density of the microparticles is usually higher than the density of the buffer fluid. Thus the microparticles tend to deposit on the bottom of the receptacle leading to an aggregation of the microparticles because of weak interactions. To obtain representative measurements a homogeneous distribution of the microparticles in the buffer fluid is necessary to ensure a constant concentration of microparticles for each analysis cycle. It is further necessary to provide disaggregation of the microparticles, which is also realized by stirring the fluid. Stirring is conducted with a rotational frequency that is adapted to the amount of fluid to be stirred.

Electrochemiluminescence method of detecting an analyte in a liquid sample and analysis system

The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

An apparatus for processing a laboratory sample contained in a laboratory sample container is presented. The apparatus comprises an optical sensing unit for sensing a transmittance at different vertical positions through the laboratory sample container and a tip sensing unit having a tip. The tip sensing unit is adapted to provide a tip sensing signal (tLDS) depending on a position of the tip relative to the sample. The apparatus also comprises a process control unit adapted to control the secure and reliable pipetting of the laboratory sample in response to both the transmittance and the tip sensing signal (tLDS) provided by the tip sensing unit.

Laboratory automation system including improved processing of a laboratory sample by optical and tip position sensing

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Penzberg, Germany

Oliver Larbolette