Basf Se Corporation

Aicuris Gmbh + Co. Kg.

Bayer Pharma Aktiengesellschaft

Merial Limited

Basf Agro B.v. Arnhem (nl), Zurich Branch

Oliver Kuhn

Mathias Berwe

Hans-Christian Militzer

Michael Keil

Wolfgang Rohde

Martin Sukopp

Michael Mentges

Jon J Longlet

Joachim Kruger

Carsten Gröning

Käthe Gooβen

Rodrigo Enrique Munizaga

Reinhold Gehring

Bernhard Schuler

Klaus Mohrs

Michael Lögers

Joachim Krüger

Werner Heilmann

Jana Lenz

David Johann Gilbert

Andreas Luz

Jürgen Stiehl

Mike Matthäus

Kathe Goossen

Matthias Müller-Gliemann

Käthe Goossen

A process for concentrating graphite particles comprising a) providing a feedstock which contains the graphite particles and an undesired material, b) adding hydrophobic magnetic particles to the feedstock which results in a loaded feedstock containing agglomerates of the magnetic particles and the graphite particles, and c) separating the agglomerates from the loaded feedstock by a magnetic field which results in isolated agglomerates.

Concentrating graphite particles by agglomeration with hydrophobic magnetic particles

The present invention relates to a process for separating at least one first material from a mixture comprising this at least one first material, at least one second material and at least one third material, which comprises at least the following steps: (A) providing a mixture comprising at least one first material, at least one second material, at least one third material and at least one hydrocarbon in an amount of more than 0.4% by weight, based on the sum of mixture, in the presence or 10 absence of at least one dispersion medium, (B) if appropriate, addition of at least one dispersion medium to the mixture obtained in step (A) in order to obtain a dispersion, (C) treatment of the dispersion from step (A) or (B) with at least one hydrophobic magnetic particle, so that the at least one first material and the at least one magnetic particle agglomerate, (D) separation of the adduct from step (C) from the mixture by application of a magnetic field, (E) if appropriate, dissociation of the adduct which has been separated off in step (D) in order to obtain the at least one first material and the at least one magnetic particle separately.

Separation of a mixture using magnetic carrier particles

Dihydroquinazolines of the formula:  The dihydroquinalzolines are useful as antiviral agents in particular against cytomegaloviruses.

Process for the preparation of dihydroquinazolines

The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent S in the presence of at least one amine acid complex wherein the amine(s) are selected from cyclic secondary amines and the acid(s) are selected from sulfonic acid derivatives, and with the addition of a halogenating agent, wherein S is [CFS(O)]O; or CFS(O)X wherein X means fluoro, chloro, bromo, iodo, a hydroxy group, or an alkaline or alkaline earth metal salt of the hydroxy group; or mixtures thereof.

Process for the sulfinylation of a pyrazole derivative

The present invention relates to a process for the preparation of dihydroquinazolines, for example, methyl (S)-{8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoro -methyl)-phenyl]-3,4-dihydroquinazolin-4-yl}acetate (2S,3S)-2,3-bis[(4-methylbenzoyl) -oxy]succinic acid salt, which are used for the production of antiviral medicaments. 

The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.

The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoro-methyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt.

Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide

The present invention relates to a process for the preparation of dihydroquinazolines, for example {8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl}acetic acid, which are used as antiviral agents in the production of medicaments.

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Rosport, Luxembourg

Oliver Kuhn