B.r.a.h.m.s Gmbh

Epigenomics Ag

Oliver Hartmann

Andreas Bergmann

Joachim Struck

Manfred Schmitt

Fabian Model

Ralf Lesche

Dimo Dietrich

Leong Loke Ng

Nadia Harbeck

Sabine Maier

Peter Adorjan

John W Martens

Antje Kluth Lukas

Beat Müller

Thomas Koenig

Heinz Hoefler

John Foekens

Inko Nimmrich

Tamas Rujan

Almuth Marx

Christian Nickel

Frauke Hein

Ina Schwope

Volkmar Mueller

Sven Giersdorf

Roland Bingisser

Thomas König

Heinz Höfler

Antje Kluth

John Martens

Volkmar c/o Department Of Gynecology Müller

The present invention relates to the determination of the level of marker peptides in a sample derived from a bodily fluid of a subject presenting with non-specific complaints.

Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with non-specific complaints

The present invention relates to a method for the stratification of a subject having an acute or a chronic disease, wherein the disease affects endothelial function/dysfunction, comprising the steps of (i) taking a sample of bodily fluid from the subject; (ii) determining in the sample of bodily fluid the concentration of a vasoactive hormone or fragments thereof or precursors or fragments thereof having a length of at least 12 amino acid residues; (iii) stratifying the subjects into either of the categories: (a) responder to a medication for treatment of the disease, (b) non-responder to a medication for treatment of the disease not showing an unfavorable effect after having received the medication; (c) subjects showing an unfavorable effect after having received the medication. The invention also relates to the use of an antibody or a functional fragment thereof in the method according to the invention.

Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction

The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

Methods for the prognosis of breast cancer

The field of the present invention is the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea. It is a subject of the present invention to provide a method for the diagnosis and/or prediction and/or therapy follow-up of bacterial infections in subjects suffering from dyspnea.

Detection of bacterial infections in subjects suffering from dyspnea

The present invention relates to an in vitro method for the diagnosis and treatment guidance of a bacterial infection in patients suffering from an acute ischemic or hemorrhagic stroke, comprising the determination of the level of Procalcitonin (PCT) or a fragment thereof having at least 12 amino acid residues in a sample of a bodily fluid from said patient and the correlation of the determined level to the diagnosis of a bacterial infection in said patient.

Procalcitonin for the diagnosis of bacterial infections and guidance of antibiotic treatment in patients with acute stroke or transient ischemic attack

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Berlin, Germany

Oliver Hartmann