Mintaka Foundation for Medical Research

Universitè De Genève

Université Pierre Et Marie Curie (paris Vi)

Hoffmann-la Roche Inc.

Novimmune Sa

Les Hôpitaux Universitaires De Genève

F. Hoffmann-la Roche Ag

Oliver Hartley

Robin E Offord

Patrice Debre

Hubert Gaertner

Guy Gorochov

Karim Dorgham

Nicolas Fischer

Priscila Camillo Teixeira

Paul Cutler

Séverine Fagète

Nicolas Vuilleumier

Philippe Ferber

Sabrina Pagano

Provided herein are display systems for simultaneously displaying two different ligand binding polypeptides at the surface of a phage. Also provided are kits, methods of using such display systems and methods of discovering novel bispecific antibodies.

Antibody dual display dual compositions and methods of use thereof

The invention relates to mimetic peptides of epitope(s) of Apolipoprotein A-I, diagnostic immunoassays comprising such mimetic peptides, as well as methods for diagnosing and methods for preventing and/or treating a cardiovascular disease.

Mimetic peptides

The invention relates to polypeptides comprising an N-terminal portion and a C-terminal portion, wherein said N-terminal portion comprises the signature sequence QGP[P or L] and the amino acid sequence of said C-terminal portion is at least 70% identical to SEQ ID NO: 1, and uses thereof.

Cytokine derivatives

The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications. Such applications include drag and gene delivery, tumour targeting, bioimaging, tissue remodelling, generation of antiviral products and vaccines delivery.

Decorated macromolecular scaffolds

The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.

Methods for construction and screening of libraries of chemokine variants

Methods and construction and screening of libraries of chemokine variants

Growing community of inventors

Carouge, Switzerland

Oliver Hartley