Roche Diagnostics Operations, Inc.

Ventana Medical Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Oliver Gutmann

Edwin Oosterbroek

Michael Glauser

Daniel Mueller

Emad Sarofim

Andreas Drechsler

Rainer Jaeggi

Chris Steinert

Reto Huesser

Raymond T Kozikowski, Iii

Melis Hazar

Heinz-Michael Hein

Goran Savatic

Martin Kopp

Rijk Edwin Oosterbroek

Michael Andreas Heinrich

Geza Burghardt

Jean-Pierre Bolliger

Norbert Schmitt

Roger Sandoz

Daniel Müller

Raymond Kozikowski

A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (), comprising at least one microfluidic reagent applicator (); at least one bulk fluid applicator (); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system () that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.

Systems and methods for staining of biological samples

A laboratory system for a laboratory automation system is presented. The laboratory system comprises a sample container carrier. The sample container carrier is configured to carry a laboratory sample container and comprises a removal detector. The removal detector is configured to interact with the laboratory sample container to detect a removal of the carried laboratory sample container from the sample container carrier. Furthermore, the laboratory system is configured to determine based on the detected removal that a before valid logic assignment of the sample container carrier to the carried laboratory sample container is invalid.

Laboratory system, laboratory sample distribution system and laboratory automation system

An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.

Acceleration sensitive indicator

A system for the automated analysis of liquid samples having one or more processing units for reaction between the samples and one or more reagents to thereby obtain reaction products is disclosed. Disclosed also are a sample unit for supplying the samples to the one or more processing units; a reagent unit equipped with plural reagent vessels containing one or more reagents for mixing with the samples; a distribution unit for distributing fluids including the one or more reagents provided with plural distribution lines, at least some of which are connected to the reagent vessels and the one or more processing units; and at least one analytical unit for analyzing the samples based on the reaction products, in which the analytical unit may include at least one detector for detecting the reaction products.

System for the analysis of liquid samples

A microfluidic processing unit for the automated processing of liquid samples and method thereof are disclosed. In one embodiment, the unit comprises first and second main channels connected to a pump for generating a negative or positive pressure therein; a sample channel which supplies a liquid sample is connectable to a sample vessel containing the liquid sample, the sample channel communicates with the first main channel and is equipped with an on/off valve; one or more reagent channels for supplying one or more reagents, the reagent channels being connectable to reagent vessels containing reagents for reacting with the liquid samples, each of the reagent channels communicating with the first or second main channel and being equipped with an on/off valve; and a reaction chamber for reacting a sample and reagent, the reaction chamber being connected to the first and second main channels via at least one on/off valve.

Processing units and methods for the processing of liquid samples

Growing community of inventors

Thalwil, Switzerland

Oliver Gutmann