Sterix Limited

Oliver Brook Sutcliffe

Michael John Reed

Barry Victor Lloyd Potter

Atul Purohit

Lok Wai Lawrence Woo

Christian Bubert

Paul Michael Wood

Christian Burbert

The present invention relates to steroid sulphatase and/or aromatase inhibitors of Formula III or Formula IV, wherein A is selected from H, OH, halogen and hydrocarbyl; D, E and F are each independently of each other an optional linker group; P, Q and R are independently of each other a ring system, wherein Rand Rare independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl or optionally contain one or more hetero atoms or groups, and which can be used in medicine.

Sulfamic acid ester compounds useful in the inhibition of steroid sulphatase activity and aromatase activity

There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, &#x2014;F&#x2014;R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CHand C&#x2550;O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

Compound

Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase

There is provided a compound of Formula Iwherein each T is independently selected from H, hydrocarbyl, &#x2014;F&#x2014;R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CHand C&#x2550;O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

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Oxford, United Kingdom

Oliver Brook Sutcliffe