Memorial Sloan Kettering Cancer Center

Ludwig Institute for Cancer Research Limited

Agenus Inc.

Olga Shebanova

Gerd J Ritter

Taha Merghoub

Marc A Van Dijk

Nicholas Stuart Wilson

Jedd David Wolchok

David Schaer

David Adam Savitsky

Cornelia Anne Mundt

Mark Arthur Findeis

Jean-Marie Cuillerot

Igor Proscurshim

Dennis John Underwood

Roberta Zappasodi

Rikke Baek Holmgaard

The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CTLA-4 antibodies and methods of use thereof

Provided are antibodies that specifically bind to CTLA-4 and/or PD-1 and antagonize CTLA-4 and/or PD-1 function. Also provided are pharmaceutical compositions and kits comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies either alone or in combination.

Antibodies and methods of use thereof

Growing community of inventors

Somerville, MA, United States of America

Olga Shebanova