Centro De Ingeniería Geneética Y Biotechnología

Olga Lidia Pérez Guevara

Gerardo Enrique Guillén Nieto

Lázaro Gil González

Alienys Izquierdo Oliva

Ernesto Marcos López

Edith Suzarte Portal

María Guadalupe Guzmán Tirado

Iris Valdés Prado

Angelica De La Caridad Garcia Arechavaleta

Mayling Alvarez Vera

Jorge Castro Velazco

Lázaro López Fernández

Rosa Liset Ramírez Bartutis

Yusleidi De La Caridad Pérez Fuentes

Yaremy Romero Fernández

Vaccine compositions that comprise at least one antigen based on the dengue virus (DV) capsid protein and the oligonucleotide identified as SEQ ID NO 1. The vaccine composition that comprises a fusion protein formed by the DV2 capsid and domain III of the envelope protein of the same serotype, together with the oligonucleotide identified as SEQ ID NO 1, gives rise to higher levels of cellular immune response and protection in mice as compared with that produced by formulations of the same antigen together with oligonucleotides with potential adjuvant capacity which were reported previously. The efficacy of the compositions that comprise the SEQ ID NO 1 oligonucleotide has been demonstrated in non-human primates. These compositions may be monovalent, bivalent or tetravalent and are combined in different immunization regimes with a view to inducing a functional immune response to the four viral serotypes.

Dengue virus vaccine composition

Growing community of inventors

La Habana, Cuba

Olga Lidia Pérez Guevara