Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Olga Gurevitch

Shimon Slavin

Gideon A Rodan

Michael Chorev

Itai A Bab

Dan Gazit

John W Jacobs

Andras Muhlrad

Tatyana Prigozhina

Nura Mansur

Zvi Greenberg

Arye Shteyer

Mohinder K Sardana

Basan Gowda S Kurkalli

A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for use in bone marrow transplantation, into bone marrow cavity or into extraskeletal sites, and methods of transplantation/implantation thereof. The composition and methods of the invention enable restoring and/or enhancing the formation of hematopoiectic microenvironment originating from the transplanted BMC, and are useful in the treatment of hematopoietic disorders, such as deficiency of stem cells and/or their products, genetic conditions resulting in abnormal stem cells and/or products, or hematopoietic disorders of malignant or non-malignant origin. The composition and method of the invention may also be used for the induction of graft tolerence, for the prevention of graft-v-host disease. It is mostly important that the compositions and methods of the invention may be applied for the treatment of diseases affecting primarily or secondarily the stromal microenvironment that supports and regulates hematopoiesis. Further provided is a kit for transplantation into a mammal of BMC in admixture with DBM and/or MBM.

Methods of treatment of hematopoietic disorders

A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino acid sequence of

Osteogenic growth polypeptides identified from regenerating bone marrow

Growing community of inventors

Jerusalem, Israel

Olga Gurevitch