Merck Sharp + Dohme Corp.

Merck Sharp & Dohme De Espana Sa

Merck + Co., Inc.

Olga Genilloud

Sheo B Singh

Deborah L Zink

Angela Basilio

Jun Wang

David Brian Olsen

Michael A Goetz

Francisca Vicente

Jon D Polishook

Brian Heimbuch

Ana M Teran

Magda M Gagliardi

Hiranthi Jayasuriya

Ignacio P Gonzalez

Scott Knoble Smith

Oscar Salazar

Pilar Hernandez

Jose Rueben Tormo

Sheo Bux Singh

Jose Ruben Tormo

Ignacio Gonzalez

The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds. 

Extracts from kibdelos porangium as antibacterial agents

Fermentation of a nutrient medium with a eubacteriumsp. yields a novel antibacterial compound of structural formula (I). 

Antibiotic compound

Fermentation of a nutrient medium with a eubacteriumsp. yields a novel antibacterial compound of structure (I). 

Antibiotic compounds

Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Actinoplanes sp. MA7220 (ATCC 202188) is also disclosed, as well as processes for making compounds of the present invention employing the culture.

HIV integrase inhibitors

Growing community of inventors

Madrid, Spain

Olga Genilloud