University of Florida Research Foundation, Incorporated

Oleksandr Kondratov

Sergei Zolotukhin

Provided herein are methods and compositions useful in the production of recombinant AAV (rAAV) in host producer cells, such as insect cells. In some embodiments, methods, uses and compositions are provided that comprise recombinant VP1 genes comprising modified Kozak sequences to express AAV VP1 proteins in amounts that are useful for producing infective rAAV particles. These infective rAAV particles may comprise a gene of interest.

Methods of enhancing biological potency of baculovirus system-produced recombinant adeno-associated virus

Provided herein are methods and compositions useful in the production of recombinant AAV (rAAV) in insect cells. In some embodiments, methods and compositions include the use of modified Kozak sequences to express AAV VP1 proteins in amounts that are useful for producing infective rAAV particles.

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Gainesville, FL, United States of America

Oleksandr Kondratov