Forschungszentrum Juelich Gmbh

Forschungszentrum Julich Gmbh

Priavoid Gmbh

Oleksandr Brener

Dieter Willbold

Luitgard Nagel-Steger

Daniel Frenzel

Lothar Gremer

Julian Glueck

Dieter Willibold

Julian GLÜCK

A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-&#x3b2; (A&#x3b2;) conformers, comprising the steps of: &#x2014;fractionating a sample including various A&#x3b2; conformers; &#x2014;immobilizing a biotinylated A&#x3b2; conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and &#x2014;deriving the binding behavior of an aggregate quality control probe to the desired A&#x3b2; conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.

Method for quantitative characterization of substances with regard to their properties of binding to amyloid-&#x3b2; (A&#x3b2;) conformers

A peptide comprising at least one peptide binding to an amyloid beta species, wherein the peptide includes an amino acid sequence that is present in cyclized form. The use of the peptides in medicine, in particular for treating Alzheimer's disease, is disclosed.

Cyclic, amyloid beta-binding peptides and the use thereof

A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising:&#x2014;providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape;&#x2014;adding an active ingredient to be analyzed to the sample solution;&#x2014;separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape;&#x2014;optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks;&#x2014;determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.

Method for the quantitative characterization of amyloid and/or aggregating peptides and/or proteins in a sample

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Duesseldorf, Germany

Oleksandr Brener