Centre National De La Recherche Scientifique

Institut Pasteur De Lille

Université De Lille 1 - Sciences Et Technologies

Université De Lille

Université De Lille 2 Droit Et Santé

Universitá Degli Studi Di Pavia

Université Lille 2 - Droit Et Santé

Innobiochips

Universite De Lille Ii

Oleg Melnyk

Dominique Bonnet

Helene Gras-Masse

Jean-Olivier Durand

Claude Auriault

Nathalie Ollivier

Julien Dheur

Reda Mhidia

Line Bourel

Laurent Raibaut

Vincent Aucagne

Agnes Delmas

Ermanno Gherardi

Hélène Gras-Masse

Agnès Delmas

Jean-Philippe Georges Bernard Ebran

Eric Adriaenssens

Hugo De Jonge

Nabil Dendane

Vianney Souplet

Christophe Olivier

Jerome Vicogne

Berenice Leclercq

Jean-Sebastien Fruchart

Claire Simonneau

Giovanni De Nola

Julien Philippe Dheur

Ahmed Bouzidi

Jean-Michel Garcia

Xavier Duburcq

Ouafâa El-Mahdi

Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.

MET receptor agonist proteins

Method for preparing a peptide assembly of n fragments and n&#x2212;1 amino acids bearing a thiol function, represented by the formula:A-C-A-C-A- . . . -C-A- . . . -C-A&#x2003;&#x2003;(I)in which A, A, A, . . . A. . . , Aare peptide fragments, C, C, C. . . C. . . Care amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A-SR (II) in which Ais a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.

Method for preparing peptides by assembling multiple peptide fragments

A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.

Native ligation process

The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.

Method for functionalizing surfaces for analyte detection

Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. The invention also relates to kits for applying this synthesis method as well as test and/or diagnostic kits.

Method for synthesizing proteins

The invention mainly relates to a method for manufacturing a polypeptide of formula:X&#x2014;X&#x2033;&#x2014;X&#x2003;&#x2003;(III)Xand Xeach representing a peptide fragment, and X&#x2033; representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula:X&#x2014;N(CHCHSH)&#x2003;&#x2003;(I)and a polypeptide of formula:H&#x2014;X&#x2033;&#x2014;X.&#x2003;&#x2003;(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.

Method for native ligation of polypeptides

The invention relates to a functionalised solid support for the synthesis of compounds comprising at least one &#x3b1;-oxoaldehyde function, to a process for preparing it and to its applications, in particular for the preparation of a library of organic compounds, of a diagnostic reagent, of a microtitration plate and of a biochip, such as a DNA chip. The present invention also relates to a process for the synthesis of organic compounds comprising at least one &#x3b1;-oxoaldehyde function and to the &#x3b1;-oxoaldehyde peptides obtained using this process.

Functionalised solid support for alpha-oxoaldehyde synthesis

The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.

Method for binding, in solution, a peptide and a lipophilic vector and uses thereof

Growing community of inventors

Annoeullin, France

Oleg Melnyk