Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Olaf Heindenreich

David Brian Olsen

Wolfgang A Pieken

Fritz Eckstein

Fritz Benseler

David M Williams

The claimed invention is drawn to RNA molecules with catalytic activity comprising at least one modified nucleoside having a modifier group replacing the hydroxy group at the 2'-position of the ribose sugar where the modifier group is an halo, amino, mono- or disubstituted amino, or an azido group, and methods of use in vivo.

Modified ribozymes

The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino, and disubstituted andno groups, a process for the preparation of modified KNA molecules and the use of modified KNA molecules as therapeutic agents and biocatalysts.

Growing community of inventors

Gottingen, Germany

Olaf Heindenreich