Roquette Freres

Olaf Haeusler

Daniel Wils

Juergen Siepmann

Denis Simon

Philippe Lefevre

Solène Bock

Nicolas Descamps

Rajeev Gokhale

Gregory Le Bihan

Stefanie Krenzlin

Youness Karrout

Marie-Helene DeGrave

Merveille Nono

Keat-Theng Chow

Yuan-Siang Lui

Solene Bock

Marie-Hélène Degrave

Stéfanie Krenzlin

The present invention relates to the use of octenyl succinate starch, in particular sodium octenyl succinate starch as a binder in wet granulation, in particular for pharmaceutical solid dosage form and the granule obtainable by the method thereof.

Use of octenyl-succinate starches as a binder in wet granulation

The invention relates to a novel glucose polymer which is particularly useful for administration by the parenteral route, and to the method for the production thereof. The invention also relates to compositions comprising such a glucose polymer, and to the methods for the production thereof. The invention further relates to the use thereof as a medicament, for example as an osmotic agent for peritoneal dialysis.

Glucose polymers for peritoneal dialysis

One subject of the present invention is the use of a combination of a polyol (i) consisting of 12 carbon atoms and of a polyol (ii) consisting of 4 to 6 carbon atoms, as protein stabilizer. Another subject of the present invention is protein compositions comprising such a combination. A final subject of the present invention is a process for preparing protein compositions using such a combination.

Use of particular combinations of carbohydrates for stabilizing proteins, and protein compositions containing such combinations

A controlled-release oral pharmaceutical composition of at least an active agent, including: a) a lipophilic matrix consisting of lipophilic compounds and/or amphiphilic compounds; and b) an hydrophilic matrix, wherein the hydrophilic matrix includes at least an indigestible polysaccharide, the active ingredient being dispersed in the lipophilic and/or the hydrophilic matrix. The present invention also relates to a process for the preparation of such a pharmaceutical composition.

Modified starch derivative-based matrix for colon targeting

A controlled release pharmaceutical dosage form for controlled release of an active ingredient, includes an active ingredient coated by a polymeric mixture of: at least a water insoluble polymer; and at least an indigestible water-soluble oligosaccharide. The use and method of making the same are also described.

Water insoluble polymer: indigestible water-soluble polysaccharide film coatings for colon targeting

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Fletre, France

Olaf Haeusler