USA As Represented by Secretary of the Navy

Okhil Nag

James B Delehanty

Jeffrey R Deschamps

Kimihiro Susumu

Eunkeu Oh

Alan L Huston

Igor L Medintz

Philip E Dawson

Michael H Stewart

Alexander L Efros

Lauren D Field

Igor Vurgaftman

Mijin Kim

R Joseph Weiblen

Scott Walper

Parag Chitnis

John R Cressman

D Andrew Knight

Gregory Ellis

Kwahun Lee

Katherine Rogers

Ajmeeta Sangtani

Nashaat Rasheed

A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.

Seedless synthesis of anisotropic gold nanoflowers with cellular control and drug delivery applications

A rhodium-loaded porphyrin complex, comprising the porphyrin (meso-tri(4-sulfonatophenyl) mono(4-carboxyphenyl)porphine (C1S3TPP)) with coordinated with rhodium, effectively neutralizes the biological activity of naturally-occurring and synthetic opioids.

Metal-porphyrin complexes for the inactivation of the biological activity of opioids

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Emission correlates with cellular membrane potential.

Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.

Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential

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Alexandria, VA, United States of America

Okhil Nag