Seoul National University

University of Pennsylvania

Ohsang Kwon

Jin Yong Kim

Seong M Jo

George Cotsarelis

Yoo-Wook Kwon

Kyu Han Kim

Hye-In Choi

Bo Mi Kang

Provided is a medium composition for differentiation of a human induced pluripotent stem cell to a dermal papilla precursor cell, a differentiation method, and a use for inducing hair follicle neogenesis using the differentiated dermal papilla precursor cell. Further provided is a method for differentiating a human induced pluripotent stem cell into a dermal papilla precursor cell having hair follicle forming ability and a composition of a dermal papilla precursor cell specific differentiation medium for the above differentiation, and have effectively induced hair follicle neogenesis consisting only of human cells without conventional mouse-human hybrid hair follicles by using the human induced dermal papilla precursor cell and a human induced epidermal precursor cell obtained through the differentiation method. Human hair follicle tissue produced is expected to be useful as a therapeutic method for patients suffering from hair loss by overcoming the limitations of hair loss treatments.

Method of differentiation of human induced pluripotent stem cell to dermal papilla precursor cell and use thereof

Provided herein is a method of preventing hair loss or promoting hair growth, the method including administering an effective amount of a PDE 3 inhibitor. More particularly, when the method of the present disclosure is used, an excellent hair loss prevention or hair growth promotion effect is obtained by inhibiting the activity of PDE 3.

Method of preventing hair loss or promoting hair growth by using phosphodiesterase 3 inhibitor

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Seoul, South Korea

Ohsang Kwon