Samsung Life Public Welfare Foundation

Samsung Electronics Co., Ltd.

Sungkyunkwan University

Ajou University Industry-Academic Cooperation Foundation

S & E Bio Corporation

Oh Young Bang

Gyeong Joon Moon

Dong Hee Kim

Jae Min Cha

Ji Hee Sung

Yeon Hee Cho

Suk Jae Kim

Ji Hyun Lee

Geon Ha Kim

Pyoung Jeon

Eun Kyoung Shin

Woo-Keun Seo

Young Hwan Ahn

Yoon-Chul Kim

Jong-Won Chung

Soo Kyung Ryoo

Ji Yoon Nam

Gyeong-Moon Kim

Phil Hyu Lee

Eun Hee Kim

Jeong Pyo Son

According to an embodiment of the present disclosure, there is provided a method of predicting a brain tissue lesion distribution, the method including: a model learning operation of learning a prediction model for predicting a brain tissue lesion distribution of a subject by using brain image data of a plurality of previous patients; an input obtaining operation of obtaining input data from brain image data of the subject; and an output operation of generating output image data including information on the lesion distribution after recanalization treatment for the subject, by using the prediction model. The prediction model includes a success prediction model that is learned by using data of patients in which recanalization treatment is successful among the plurality of previous patients, and a failure prediction model that is learned by using data of patients in which recanalization treatment fails among the plurality of previous patients.

Method, device, and computer program for predicting brain tissue lesion distribution

Provided are a method for producing stem cell-derived extracellular vesicles by using a three-dimensional cell culture process, use of three-dimensional cell aggregates of stem cells in producing extracellular vesicles, a culture of three-dimensional cell aggregates of stem cells comprising a high concentration of extracellular vesicles, and a pharmaceutical composition comprising the culture.

Method for producing stem cell-derived extracellular vesicle

The present invention relates to stem cell-derived microvesicles with enhanced efficacy, a use thereof, and a method for enhancing efficacy, and more particularly, to a use of stem cell-derived microvesicles with an enhanced expression level of microRNAs for the prevention or treatment of stroke, and a method for promoting the production of microRNAs of stem cell-derived microvesicles and enhancing efficacy, and a method for promoting the production of stem cell-derived microvesicles and microRNAs within the microvesicles and enhancing the efficacy of stem cells and microvesicles thereof by 3-dimensionally culturing or ischemically stimulating stem cells. Since the method according to the present invention has excellent effects capable of promoting the production of stem cell-derived microvesicles and microRNAs in the microvesicles and capable of enhancing the efficacy of stem cells or microvesicles isolated therefrom, it is possible to obtain stem cell-derived microvesicles containing high levels of materials including therapeutic microRNAs efficiently and in large quantities through this, and thus, the microvesicles are expected to be able to be usefully used in related research fields and future clinical settings.

Stem cell-derived microvesicles with enhanced efficacy, use thereof, and method for enhancing efficacy

The present invention relates to a composition including stem cell-derived microvesicles as an active ingredient for promoting neurogenesis. The stem cell-derived microvesicles according to the present invention can promote neurogenesis and migration of nerves and also promote angiogenesis in vascular endothelial cells, and thus can be usefully used in treatment of neurological damage.

Composition including stem cell-derived microvesicles for promoting neurogenesis

The present invention relates to a composition comprising an ischemic serum for promoting the activation of a stem cell, to a method for promoting the activation of a stem cell and to a stem cell, the activation of which is promoted by the composition or the method. The ischemic serum according to the present invention may stimulate the stem cell to facilitate the secretion of a growth factor, improve survival rate, improve mobility to an injured part, improve proliferation rate and maintain characteristics of the stem cell, thus promoting an activation of the stem cell such that the stem cell becomes suitable for transplantation of the stem cell to a patient having a brain injury.

Composition comprising ischemic serum for promoting activation of stem cell and method for promoting activation of stem cell

The present invention provides a method for treating multiple system atrophy, comprising administering a therapeutically effective amount of mesenchymal stem cells (MSCs) to a human in need thereof. Preferably, the administering is performed by an intra-arterial injection of said MSCs and one or more intravenous injections of said MSCs.

Treating multiple system atrophy with hMSC

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Seoul, South Korea

Oh Young Bang