Kabushiki Kaisha Yakult Honsha

Oh Yoshida

Hiroshi Hatano

Shusuke Hashimoto

Ryuta Yamazaki

Takeshi Matsuzaki

Masato Nagaoka

Ritsuo Aiyama

Tomio Furuta

Yukiko Nishiyama

Yoshikazu Sugimoto

A breast cancer resistance protein (BCRP/ABCG2) inhibitor. The BCRP inhibitor contains, as an active ingredient, an acrylonitrile derivative or a salt thereof.

BCRP/ABCG2 inhibitor

The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [wherein, each of 8 R's, which are the same or different from one another, represents a hydrogen atom, a hydroxyl group, a nitro group, an amino group, an acetylamino group (&#x2014;NHCOCHgroup); a cyano group (&#x2014;CN group); a formyl group (&#x2014;CHO group), &#x2014;COOR(Ris hydrogen or C1-C4 alkyl), &#x2014;O(CH)COOR(n=1&#x2212;7: Ris hydrogen or C1-C4 alkyl), &#x2014;OOCCHCHCOOR(Ris hydrogen, C1-C4 alkyl, (Z)-2-(3,4-dimethoxy-phenyl)-3-(4-hydroxy-phenyl)-acrylonitrile, or glycopyranosyl), a C1-C8 alkoxy group, a C1-C4 alkyl group, a halogen atom, a C1-C4 alkoxy C1-C4 alkoxy C1-C4 alkoxy group, a C2-C8 acyloxy group, a C2-C8 halogenoacyloxy group, a methylenedioxy group, a trifluoromethyl group, a phosphate group (i.e., &#x2014;OP(O) (OH)) or a salt thereof, a sulfate group (i.e., &#x2014;OSOH) or a salt thereof, a glycopyranosyl group or a salt thereof, a phosphate ester of a glycopyranosyl group or a salt of the ester, a sulfate ester of a glycopyranosyl group or a salt of the ester, or a piperidinopiperidinocarbonyloxy group], an ester thereof, or a salt thereof.

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Minato-ku, Japan

Oh Yoshida