Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Science and Technology

Korea Research Institute of Bioscience

Og-Sung Moon

Tae-Sook Jeong

Woo-Song Lee

Hyoung-Chin Kim

Yang-Kyu Choi

Ju-Ryoung Kim

So-Jin An

Kyoung-Ran Im

Ki-Chang Jang

Jun-Seock Son

Jong-Min Han

Hyung-Jae Jeong

Yong-Dae Park

Young-Suk Won

Myung-Sook Choi

Song-Hae Bok

Chul-Ho Lee

Surk-Sik Moon

Yong-Kook Kwon

Eun-Sook Lee

Byung-Hwa Hyun

Sung-Gyu Kim

Sae-Bom Lee

Byung-Tae Ahn

The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA, because they have excellent inhibitory effect of Lp-PLA.

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A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated fromas an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated fromnot only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extractingleaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.

The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further,extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

A method for increasing the plasma high density lipoprotein(HDL) level in a mammal comprises administering a bioflavonoid of formula(I) or plant extract containing same thereto: ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5.sub.7 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are each independently hydrogen; a hydroxy group; a C.sub.1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C.sub.2-10 or C.sub.16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C.sub.1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; a rutinosyl group; or a rhaminosyl group; and

Bioflavonoids as plasma high density lipoprotein level increasing agent

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Taejeon-si, South Korea

Og-Sung Moon