State of Israel Prime Minister's Office Israel Institute for Biological Research

Israel Institute for Biological Research

State of Israel, Represented by Prime Minister's Office, Israel Institute for Biological Research

Ofer Cohen

Avigdor Shafferman

Theodor Chitlaru

Baruch Velan

Chanoch Kronman

Sagit Sela-Abramovich

Orit Gat

The invention provides an isolatedsensu lato strain, selected fromand, in which the htrA gene or any part thereof is silenced, and vaccines comprising the same.

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An organophosphate scavenger is provided, with extended residence time in the mammalian circulation, which can be used in preventive and therapeutic treatment of organophosphate poisoning. The scavenger is a uniformly pegylated serine hydrolase, in which a part of lysine residues were replaced with other residues by site-directed mutagenesis. One part of lysine residues in the hydrolase amino acid sequence is selected for the PEG-coupling, and the other part for the replacement, wherein the selection should ensure that the hydrolase surface shows at least one free amino acid for PEG coupling for all possible views obtained by rotating a 3-D model generated for the hydrolase.

Uniformly conjugated serine hydrolases

A novel and rapid diagnostic method for anthrax infection is provided. Threegene products are described, as well as antibodies against the same, which may be used for the detection and monitoring of anthrax infection. Kits for the diagnosis of anthrax are also provided.

A circulatory long-lived cholinesterase (ChE) protein, such as acetylcholinesterase (AChE) or butyrylcholinesterase (BChE), which is a ChE protein modified with a non-antigenic polymer. The ChE may be AChE, such as native AChE of mammalian origin or of non-mammalian origin, or recombinant AChE. The recombinant AChE may be mutated at one or more amino-acid residues. The BChE may be native BChE of mammalian origin or of non-mammalian origin.

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Moshav Netaim, Israel

Ofer Cohen