Centre National De La Recherche Scientifique

Odile Thoison

Joanna Bakala

Jérôme Bignon

Maxim Egorov

Maria Conception Achab

Pascal Collin

Bernard Delpech

Michel Benechie

Jérome Bignon

Maria Achab

The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n&#x2267;1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO, CF, CCI, CN, COH, (C&#x2550;O)NR, CH&#x2550;NR, (C&#x2550;S)OR, (C&#x2550;O)SR, CSR, SOR, SONR, SOR, P(O)(OR), P(O)(R), B(OR)group where R is a (C-C) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and Rand Reach represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C-C) alkyl, phenyl or phenyl-(C-C)-alkyl group, in which Rand Rform, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C-C) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same. 

N-substituted 3,4-bis (catechol) pyrrole compounds, and the preparation and use thereof in the treatment of cancer

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Palaiseau, France

Odile Thoison