Sanofi-aventis

Sanofi

Sanofi-synthelabo

Sanotl-aventis

Odile LeClerc

Alistair Lochead

Frederic Galli

Julien Vache

Frédéric Galli

Patrick Andre Lardenois

Alain Nedelec

Mourad Saady

Yannick Evanno

Laurent Dubois

Franck Slowinski

Thierry Gallet

André Malanda

Omar Ben Ayad

The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.

Azabicycloalkane derivatives, preparation thereof and use thereof in therapy

The invention relates to compounds having general formula (I), wherein R is as defined herein.  The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.

Derivatives of 5-pyridazinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics

Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics

The present invention discloses and claims compounds of general formula in which X, R, P, Q, R and W are as described herein. The compounds of the invention are useful in a variety of therapeutic applications.

1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof

This disclosure relates to compounds of formula (I): wherein X, X, X, X, n, Y, W, and A are as defined in the disclosure, or a salt thereof, or a hydrate or solvate thereof, and to processes for the preparation of these compounds and the therapeutic use thereof.

N-azabicyclic carboxamide derivatives, preparation thereof and therapeutic use thereof

The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.

The invention relates to a compound of formula (I): Wherein R, X, P, Q, R and W are as defined herein. The invention also relates to the use of same in therapeutics.

Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide, preparation method thereof and use of same in therapeutics

Compounds complying with the general formula in which R either represents a halogen atom or a phenyl group substituted by one or more groups chosen from halogen atoms and (C-C)alkyl, (C-C)alkoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, or represents a pyridinyl group, a thienyl group, an indolyl group, or a pyrimidinyl group optionally substituted by one or more (C-C)alkoxy groups, where, of the two carbon-carbon bonds represented by, one is single and the other may be single or double. The compounds of this invention are useful as therapeutic agents.

Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, their preparation and their therapeutic application

The present invention discloses and claims compounds of general formula in which X represents a nitrogen atom or a group of formula C&#x2014;R, P represents a group of formula C&#x2014;R, Q represents a group of formula C&#x2014;R, R represents a group of formula C&#x2014;R, W represents a group of formula C&#x2014;R, or one of the symbols P, Q, R and W represents a nitrogen atom, Rrepresents a hydrogen atom or an alkyl group, Rrepresents a hydrogen atom or an alkyl group, R, R, Rand Reach represent a hydrogen or halogen atom, or an alkyl, alkoxy, nitro, amino, trifluoromethyl, cyano or amino group or other functional groups. The compounds of the invention are useful in a variety of therapeutic applications.

1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof

Compounds complying with the general formula (I) in which R either represents a halogen atom or a phenyl group substituted by one or more groups chosen from halogen atoms and (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, or represents a pyridinyl group, a thienyl group, an indolyl group, or a pyrimidinyl group optionally substituted by one or more (C&#x2013;C)alkoxy groups, where, of the two carbon-carbon bonds represented by, one is single and the other may be single or double. Therapeutic application.

Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics

Compound corresponding to the general formula (I) in which Rrepresents a chlorine atom, a methyl group or a 3-thienyl group. Therapeutic application.

4-(oxazolopyridin-2-yl)-1,4-diazabicyclo-[3.2.2]nonane derivatives, preparation and therapeutic use thereof

The invention relates to compounds of the Formula I, to pharmaceutical compositions comprising them, and to the method of use thereof in the treatment or prevention of disorders linked to a dysfunction of the nicotinic receptors.

4-(Oxadiazol-3-yl)-1,4-diazabicyclo[3.2.2]-nonane derivatives, preparation and therapeutic use thereof

Compound corresponding to the general formula (I)in which R, R, R, Rand Reach represent a hydrogen or halogen atom or a nitro, amino, trifluoromethyl, trifluoroalkoxy, cyano, hydroxyl, (C&#x2013;C)alkyl or (C&#x2013;C)alkoxy group and Rrepresents a (C&#x2013;C)alkyl group. Therapeutic application.

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Massy, France

Odile LeClerc