Schering Corporation

Other

Institut National De La Sante Et De La Recherche Medicale

Schering-plough Corporation

Laboratoires Unicet

Odile Djossou

Francois Fossiez

Jacques F Banchereau

Pierre Golstein

Eric Rouvier

Serge J E Lebecque

Pierre Garrone

Leopoldo Flores-Romo

Richard Murray

Serge J Lebecque

Mala Krishna

Helene Cabrillat

Catherine Favre

John Wijdenes

Human CTLA-8 protein, antibodies that specifically bind to human CTLA-8, and nucleic acids encoding human CTLA-8. Methods of using these molecules and diagnostic kits are also provided.

Monoclonal antibodies to human CTLA-8 (IL-17A)

CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.

Nucleic acids encoding CTLA-8; and related reagents

Purified mammalian CTLA-8 antigens and related reagents

Compositions and methods for using CTLA-8 to treat an abnormal physiological condition in an individual. The methods comprise administering a therapeutically effective amount of CTLA-8 alone, or in combination with other therapeutic reagents; or a CTLA-8 antagonist.

Uses of mammalian CTLA-8 and related reagents

Human monoclonal antibodies against human cytokines and methods of

Monoclonal antibodies to .gamma.-interferon and hybridomas producing such antibodies are disclosed. The antibodies are preferably of the immunoglobulin subclass IgG.sub.1, .kappa., and do not bind to interferon-.alpha..sub.2.

Monoclonal antibodies to gamma-interferon, hybridomas producing such

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Francheville, France

Odile Djossou