Centre National De La Recherche Scientifique

Basf Beauty Care Solutions France S.a.s.

Universite Claude Bernard – Lyon1

Université Claude Bernard Lyon I

Odile Damour

Eric Perrier

Corinne Reymermier

Pascal Sommer

Charbel Bouez

Claudine Gleyzal

Valerie Andre

Isabelle Orly

Christian Gagnieu

Valérie Andre

Christian Collombel

Frederique Poinsignon

Jacques Marichy

Christian Echinard

Valerie Cenizo

The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for the manufacture of a composition for modulating the interaction between the LOX and NRAGE proteins to regulate the balance between the cellular phenomena of proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between LOX and NRAGE is absent or altered. The invention makes it possible especially to treat and/or prevent skin ageing, lichen planus, graft-versus-host reaction (GVH), eczema, psoriasis and a cancer, particularly an epithelial cancer and more particularly a cutaneous epithelial cancer of basocellular or spinocellular type.

Substance for restoring normal co-expression and interaction between the LOX and NRAGE proteins

The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.

Stimulation of the synthesis of the activity of an isoform of lysyl oxidase-like LOXL for stimulating the formation of elastic fibers

This biomaterial comprises at least a compound consisting of an association of collagen, chitosan acetylated to a degree of acetylation between about 10 and about 40% and of glycosaminoglycans. It has its application in orthopedics and plastic surgery and for making extracellular matrices for regeneration of nerve cells and bones as well as biocompatible envelopes. A particular application is the making of artificial skin consisting of a dermal layer of the velvet type obtained from biomaterials such as those described above. The process of obtaining this dermal layer consists in adding a collagen solution of the chitosan, then in adding to the collagen-chitosan a mixture of chondroitins 4- and 6-sulfate.

Biomaterials with a base of mixtures of collagen, chitosan and

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Saint Genis Laval, France

Odile Damour