Chemagis Ltd.

Oded Friedman

Joseph Kaspi

Oded Arad

Edna Danon

Boris Freger

Lior Zelikovitch

Guy Davidi

Alexander Weisman

Olga Etlin

Moshe Bentolila

Hila Isenberg

David Sondack

Efrat Manoff

Michal Hasson

Eliezer Adar

Iosef Manascu

Tamir Fizitzki

Julia Ditkovitch

Yana Seryi

A novel process for preparing (2&#x3b2;,3&#x3b1;,5&#x3b1;,16&#x3b2;,17&#x3b2;)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.

Processes for the preparation of rocuronium bromide and intermediates thereof

Provided is a method for preparing letrozole, which includes reacting an activated bis-(4-cyanophenyl)-methane with a triazole to produce letrozole, and, optionally, purifying the letrozole. Also provided are highly pure letrozole, and a method of purifying letrozole, which method includes precipitating letrozole, e.g., by selective precipitation from a reaction mixture and/or by subjecting the letrozole to one or more crystallizations.

Letrozole production process

Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into 4,4'-dicyanobenzophenone and removing 4,4&#x2032;-dicyanobenzophenone, to produce a purified letrozole product.

Letrozole purification process

The invention provides a process for the preparation of 6,6-dimethylhept-1-en-4-yn-3-ol comprising of reacting t-butylacetylene with a proton-extracting agent selected from the group consisting of an organometallic compound and metallic lithium to form a t-butylacetylide, reacting the acetylide with acrolein at temperatures between &minus;40&deg; C. to &plus;20&deg; C., quenching the reaction mixture and isolating the product.

Process for the preparation of 6,6-dimethylhept-1-en-4-yn-3-ol

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Yehiel, Israel

Oded Friedman