Koninklijke Philips Corporation N.v.

Biocartis, Nv

Oana Mihaela Piciu

Roel Penterman

Marc Wilhelmus Gijsbert Ponjee

Sieglinde Neerken

Paul Arnold Van De Wiel

Kristiane Anne Schmidt

Ron Gill

Reinhold Wimberger-Friedl

Emiel Peeters

Nicolaas Petrus Willard

Ivo Godfried Jozef Camps

Zeynep Seflek Unay

Markus Laubscher

Bart Edward Gusta Jozef Van Meerbergen

Bart Edward Jozef Gusta Van Meerbergen

Zeynep Seflek

Bart Edward Van Meerbergen

Marc Wilhelmus Ponjee

Methods and devices for detection of micro-organisms present or suspected to be present within a mammalian blood sample are provided. A selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.

Selective lysis of cells

Methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria are provided. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.

Apparatus for producing thin layers of a fluid sample for analysis, has a two dimensional array of analysis chambers (), and a branching pattern of entry channels () coupled to the array to enable the analysis chambers to be filled in parallel. The analysis chambers are planar with a height less than that of the entry channels so as to produce the thin layers when filled with the fluid sample. The array enables more spacers between chambers in a given area, so that variations in height of the chambers can be reduced, while still enabling fast filling of the chambers. The analysis chambers can be suitable for capillary filling by a specified fluid sample such as blood. A pattern of exit channels () can be coupled to the array. The entry and exit channels can form comb patterns, fingers of the comb patterns being interdigitated, and the analysis chambers being arranged between the interdigitated fingers of the comb patterns.

Preparation of thin layers of a fluid containing cells for analysis

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Delft, Netherlands

Oana Mihaela Piciu