Bausch-Lomb Incorporated

Other

O William Lever, Jr

Andrea M Lever

Joseph C Salamone

Richard V Smerbeck

Anil M Salpekar

Henry P Dabrowski

A method for improving the integrity of the corneal epithelium by introducing into the eye an effective amount of a ophthalmically compatible retinoid sufficient to enhance the integrity of the corneal epithelium.

Method for enhancing integrity of epithelium using retinoic acid

The present invention is directed to method of disinfecting a contact lens with an ophthalmically safe disinfecting aqueous solution comprising about 2.0 to about 8.0 ppm of a bis(biguanide) having the following formula: ##STR1## wherein R.sup.1 and R.sup.4 are independently selected from the group consisting of branched or unbranched alkyl having 4-12 carbon atoms, ether or thioether radical having 4-12 carbon atoms, or cycloalkyl or cycloalkyl-alky radical having 5-12 carbon atoms; R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen, alkyl having 1-12 carbon atoms, alkoxyalkyl having 1-12 carbon atoms, or cycloalkyl or cycloalkyl-alkyl having 5-12, carbon atoms; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen and alkyl radical having 1-6 carbon atoms, and A in the above formula is selected from the group consisting of a divalent alkyl, alkyloxyalkyl, or alkylsufide radical each having 4-12 carbon atoms. The invention is also directed to a method of cleaning and/or disinfecting a contact lens within a minimum soaking period that is not more than about 75 minutes.

Method for providing rapid disinfection of contact lenses

An ophthalmic artificial tear solution is described for treating irritation and dryness of the eyes with a formulation that includes polyvinylpyrrolidone, a preservative such as benzalkonium chloride, glycerin and hydroxypropyl methylcellulose, wherein the composition is an aqueous solution having isotonic properties with respect to the eye. The ophthalmic solution of the invention is characterized as having a low viscosity, preferably less than 5 cps, and a low surface tension, preferably less than 40 dynes/cm, wherein wettability, retainability and comfort of the user are enhanced.

Opthalmic solution for artificial tears

Ophthalmic solution for artificial tears

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Pittsford, NY, United States of America

O William Lever, Jr