Carnegie Mellon University

University of Pittsburgh

O Burak Ozdoganlar

Geza Erdos

Louis D Falo, Jr

Toygun Cetinkaya

Phil G Campbell

Yusuf Mert Senturk

Lisha White

Ezgi Pinar Yalcintas

Ant Yucesoy

Ali Alp Gurer

Marcel Pierre Bruchez

Gary Keith Fedder

Philip LeDuc

Xinyan Cui

Jonathan W Jarvik

Douglas John Weber

Takashi Daniel Yoshida Kozai

Peter J Gilgunn

Louis D Falo

Carmel Majidi

Yadong Wang

Zhou Yu

Mary E Wilson

Emrullah Korkmaz

Lucas A Dvoracek

Jesse A Goldstein

Kadri Bugra Ozutemiz

James Wissman

Liliana Camison Bravo

Donna Beer-Stolz

Louis Falo

Jr Falo Louis D

Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.

Biosensor tattoos and uses therefor for biomarker monitoring

A method of forming a microneedle array can include forming a sheet of material having a plurality of layers and micromilling the sheet of material to form a microneedle array. At least one of the plurality of layers can include a bioactive component, and the microneedle array can include a base portion and plurality of microneedles extending from the base portion.

Dissolvable microneedle arrays for transdermal delivery to human skin

A high-throughput method of manufacturing a liquid metal circuit may include applying a liquid metal to an alloying metal pattern on an elastic substrate to form the liquid metal circuit. The elastic substrate may have a surface area greater than 1 square inch. The liquid metal circuit may include a plurality of liquid metal circuits on the elastic substrate. Methods of using the liquid metal circuit are also described.

Liquid metal circuits and methods of making the same

A method and device for fabricating vascular networks in for tissue engineering. The vascular network is embedded in a porous scaffold and is created from a sacrificial wax template, according to one embodiment. A extrusion-based three dimensional printer is used to create the template, wherein the printer utilizes an extruder incorporating a mixer to maintain the consistency of the extrudate.

Method and device for producing vasculature through extrusion-based 3D printing

Swab

A system and method used to fabricate an implant from cartilage, where the implant can be used in reconstructive surgery. The system includes a thermoregulation device capable of maintaining a desired temperature range during milling operations. The milling machine is controlled by instructions generated from a digital model of the implant. The digital model can be a stock model or a custom model created from medical scans.

System and method for fabricating cartilage implants

The present invention relates generally to a method that is used to create three-dimensional synthetic vascular networks. Micromachining and molding techniques are used to create a template in a shape that mimics a biological network. Cellular material can be seeded around the template or a space created by the template and grown into an engineered tissue-construct.

Method for engineering three-dimensional synthetic vascular networks through mechanical micromachining and mutable polymer micromolding

Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation of the device at a predefined speed with higher positional accuracy and precision and a reduction in soft tissue damage, provided by ultrasonic assisted motion, compared to current state-of-the-art implantation methods and devices. The method includes automated loading of the device being implanted into a clamping mechanism from a cartridge holding a number of implants, referencing of the device position and orientation, referencing of the surface of the tissue into which the device is being implanted, monitoring of the tissue motion, identification of desirable implant location based on the soft tissue profile, allowance of surgeon selection and fine adjustment of the final implant location, high-speed implantation, device release and implant actuator retraction.

Apparatus and method for implantation of devices into soft tissue

A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.

Tip-loaded microneedle arrays for transdermal insertion

Growing community of inventors

Sewickley, PA, United States of America

O Burak Ozdoganlar