Lubrizol Advanced Materials, Inc.

Núria Almiñana Doménech

Antonio Vicente Ferrer Montiel

Raquel Delgado González

Cristina Carreño Serraïma

José María García Antón

Gregorio Fernández Ballester

Juan Cebrián Puche

Wim Van Den Nest

Albert Soley Astals

Mauricio Valerio Santiago

Consuelo García Hernández

Cristina Carreño Serrïma

Raquel Delgado GONZÁLEZ

A compound of formula (I) R-W-X-AA-AA-AA-AA-AA-AA-Y-Z-R, a stereoisomer and/or cosmetically acceptable salt thereof, and a method of treatment using the compound are described. In the compound, AAis Asp, Gly, Asn, Gln, Ala or no amino acid; AAis Val, Ile, Leu or Ala; AAis Tyr, Phe, Trp, Lys, Arg or His; AAis Lys, Arg, His, Pro or Val; AAis Asn, Asp, Gln or no amino acid; AAis Thr, Ala, Ser or no amino acid. The compounds are useful for the treatment of the symptoms of skin aging and, in particular, for the treatment of skin wrinkles, the treatment of a sagging appearance of the skin, and/or the reduction of facial asymmetry.

Compounds useful for the treatment and/or care of the skin, hair, nails and/or mucous membranes

Compounds of general formula (I): R&#x2014;W&#x2014;X-AA-AA-AA-AA-AA-AA-AA-Y&#x2014;Z&#x2014;R, their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

Compounds which inhibit neuronal exocytosis

Compounds of general formula (I): R-W-X-AA-AA-AA-AA-AA-AA-AA-AA-AA-Y-Z-R(I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

Compounds of general formula (I): their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, and in the treatment and/or care of the skin, particularly in the aging and photoaging of the skin, and more particularly for the treatment and/or prevention of wrinkles and/or stretch marks. 

Compounds useful in the treatment and/or care of the skin and their cosmetic or pharmaceutical compositions

Compounds of general formula (I): R-W-X-AA-AA-AA-AA-AA-AA-Y-Z-R(I) their stereoisomers, mixtures thereof, their cosmetically or pharmaceutically acceptable salts and/or its functionally equivalent variants, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.

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Barcelona, Spain

Núria Almiñana Doménech