Bristol-myers Squibb Compnay

Viiv Healthcare UK (no.5) Limited

Viiv Healthcare UK (no. 4) Limited

Yale University

Viiv Healthcare UK Limited

Ny Sin

Sing-Yuen Sit

Nicholas A Meanwell

Paul Michael Scola

Brian Lee Venables

Yan Chen

Li-Qiang Sun

Jie Chen

Alicia Regueiro-Ren

Jacob Swidorski

Xiangdong Alan Wang

Zheng Liu

Andrew Charles Good

Richard A Hartz

Alan Xiangdong Wang

Jeffrey Allen Campbell

Rita Civiello

Kuo-Long Yu

Li Xu

Keith D Combrink

Hatice Belgin Gulgeze

Piyasena Hewawasam

Zhiwei Yin

Yi Zhang

Jan Willem Thuring

Ira B Dicker

Beata Nowicka-Sans

Craig M Crews

Bradley C Pearce

Mikael Elofsson

Li-Quang Sun

Amy Ripka

Ute Splittgerber

Kyung Bo Kim

Bradley C Pearc

Alicia Regueiro-ren

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.

C-3 and C-17 modified triterpenoids as HIV-1 inhibitors

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from Ccycloalkyl, Ccycloalkenyl, Cspirocycloalkyl, Cspirocycloalkenyl, Coxacycloalkyl, Cdioxacycloalkyl, Coxacycloalkenyl, Cdioxacycloalkenyl, Ccyclodialkenyl, Coxacyclodialkenyl, Coxaspirocycloalkyl and Coxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is &#x2014;Calkyl-halo. These compounds are useful for the treatment of HIV and AIDS.

Triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:  These compounds are useful for the treatment of HIV and AIDS.

C17-aryl substituted betulinic acid analogs

Hepatitis C virus inhibitors are disclosed having the general formula: 

Hepatitis C virus inhibitors

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 bicyclic amines of triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.

C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.

C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.

C-28 amides of modified C-3 betulinic acid derivatives as HIV maturation inhibitors

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.

Modified C-3 betulinic acid derivatives as HIV maturation inhibitors

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East Hampton, CT, United States of America

Ny Sin