Fundacao Oswaldo Cruz-fiocruz

Núbia Boechat

Marcus Vinicius Nora De Souza

Antoniana Ursine Krettli

Alessandra Leda Valverde

Marco Aurélio Martins

Frederico Silva Castelo Branco

Jorge Carlos Santos Da Costa

Rodrigo De Azeredo Siqueira

The instant invention relates to compounds of formula I 

&#x3b1;-ketoacylic isoniazid compounds, process for producing said compounds, use of the compounds in the treatment of tuberculosis

The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these compounds or a salt of those as active principle and to the use of such compositions to treat, prevent or inhibit atopic diseases including asthma, rhinitis, allergic urticaria, chronic lung inflammation associated with eosinophilia, following the example of atopic asthma and chronic intestinal inflammation, as colitis for instance. The pharmaceutical composition may be available in spray form, solution, suspension, emulsion destinated to be applied by nebulization, or in any of the pharmaceutical available forms for oral or injectable use.

Compounds derived from lidocaine, pharmaceutical compositions, use and method of treatment, prevention or inhibition of disease

The present invention refers to new compounds derived from artesunate salts with quinolines represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III) depending on the radicals substituted in X (formula II), the relation X to Y (formula III) may vary from 1:1 to 1:7, because the amount of Y depends on the amount of N available in X for the formation of the salt. The radicals R, R, R, R, R, e Rin the general formula (II) are represented by: R&#x2550;H, CF, CH, OCH, NH, halogen; R&#x2550;H, CH, NH, halogen, NH&#x2014;CHCH(CH)N(CH)(CHCHOH), CH(OH)-2(C5HN), NH&#x2014;R&#x2014;N&#x2014;(C2H5); R&#x2550;H, m-OCHCF, NH; R&#x2550;H, CH, OCH, NH, halogen; R&#x2550;H, CH, CF, NH, halogen; R&#x2550;H, CF, CH, NH, halogen, NH&#x2014;R&#x2014;N&#x2014;(CH), NHCH(CH)(CH)NH; R&#x2550;(CH), (CH), CHCHCH, (CH), (CH), CHCH(CH)(CH), (CH), (CH), (CH); R&#x2550;CHCH(CH), CHCH(CH)CHCH, (CH), (CH), (CH), (CH)O(CH). The present invention also refers to a process of preparation of these general formula (I) compounds, and the pharmaceutical compositions, in which these compounds are included especially their use as medicine for treatment or prevention or inhibition of malaria or other parasitic diseases such as: kaodzera, Chagas disease, leishmaniasis, amoebiasis, giardiasis, trichommoniasis, toxoplasmosis, schistosomiasis, as well as other helminthiases.

Compounds derived from artesunate, preparation process, pharmaceutical composition and use of the respective medicine

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Rio de Janeiro, Brazil

Núbia Boechat