Eli Lilly and Company

Nuria Diaz Buezo

Concepcion Pedregal-Tercero

Charles Howard Mitch

Celia Lafuente Blanco

Jose Antonio Martinez Perez

Gema Consuelo Sanz Gil

David Lee McKinzie

Julian Priego Soler

Kumiko Takeuchi

Russell Dean Stucky

Prabhakar Kondaji Jadhav

Miles Goodman Siegel

Marta Garcia De La Torre

Maria Angeles Martinez-Grau

Douglas Richard Stack

Maria-Jesus Blanco-Pillado

Mark Donald Chappell

Joseph Michael Gruber

Francisco Javier Agejas-Chicharro

Steven James Quimby

William Glen Holloway

Chad Nolan Wolfe

Jayana Pankajkumar Lineswala

Howard Barff Broughton

Alma Maria Jimenez-Aguado

Elizabeth Marie Thomas

Miguel Angel Toledo Escribano

Ana Belen Benito Collado

James Edward Matt

Dana Rae Smith

Ana Belén Bueno Melendo

James Erwin Fritz

David Lee Mckinzie

James Edward Junior Matt

In an embodiment, the present invention provides a compound of the formula: wherein or

6-methoxy-3,4-dihydro-1H-isoquinolin compounds

The present invention provides compounds of the Formula or a pharmaceutically acceptable salt thereof, and compounds processes for preparing the compounds and their salts, and a pharmaceutical composition.

Pyrrolidine compounds

The present invention provides compounds of the Formula wherein L is selected from the group consisting of &#x2014;CHNHCH&#x2014;, &#x2014;CHNH&#x2014;, &#x2014;NH&#x2014;, &#x2014;S&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;S(O)&#x2014;, &#x2014;O&#x2014;, &#x2014;OCH&#x2014;, &#x2014;OCHCHO&#x2014;, &#x2014;NHSONH&#x2014;, or a pharmaceutically acceptable salt thereof; a compound of the formula: processes for preparing the compounds and their salts, a pharmaceutical composition, and methods of treating patients in need of such treatment.

The present invention provides compounds of Formula I. Wherein R1, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the compounds. 

Benzyl sulfonamide compounds useful as MoGAT-2 inhibitors

An ORL-1 receptor antagonist of the formula: its uses, and methods for its preparation are described.

Spiropiperidine compounds as ORL-1 receptor antagonists

A selective kappa opioid receptor antagonist useful for treating ethanol use disorder withdrawal and anxiety, and/or depression, or schizophrenia as independent comorbid conditions.

Kappa selective opioid receptor antagonist

A selective kappa opioid receptor antagonist, (S)-3-Fluoro-4-[4-[2-(3,5-dimethylphenyl)pyrrolidin-1-yl-methyl]phenoxy]benzamide or a pharmaceutically acceptable salt thereof, useful for treating ethanol use disorder withdrawal, and anxiety and/or depression, or schizophrenia as independent comorbid conditions.

A compound of the formula (I); wherein the variables Xto X, Rto Rincluding R, E, W, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed. 

Opioid receptor antagonists

A compound of the formula (I) wherein the variables Xto X, Rto Rincluding R, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed 

Diaryl ethers as opioid receptor antagonist

A compound of the formula (I) (I) wherein the variables X1 to X6, Ra, Rb, R1 to R7 including R3', E, p, j, y, z, A, B and C are as described or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed 

Growing community of inventors

Madrid, Spain

Nuria Diaz Buezo