Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut Curie

Abivax

Noëlie Campos

Jamal Tazi

Didier Scherrer

Romain Najman

Aude Garcel

Florence Mahuteau-Betzer

Florence Mahuteau

Florence Mahuteau-betzer

Audrey Vautrin

Pauline Fornarelli

Julian Venables

A use of at least one miRNA, said at least one miRNA being miR-124, as a biomarker, in particular of a viral infection, or of an efficacy of a therapeutic treatment of said viral infection.

miRNA-124 as a biomarker

Methods for preventing or treating retroviral infection not HIV and/or for preventing, inhibiting or treating a disease caused by the retroviral infection include contacting a cell with compound (I)  means a pyridazine, pyrimidine or pyrazine group, R independently represent a hydrogen atom, halogen atom or group chosen among a &#x2014;CN, hydroxyl, &#x2014;COOR, (C-C)fluoroalkyl, (C-C)fluoroalkoxy, &#x2014;NO, &#x2014;NRR, (C-C)alkoxy, phenoxy and (C-C)alkyl group, the alkyl being optionally mono-substituted by hydroxyl group, n is 1, 2 or 3, n' is 1 or 2, R&#x2032; is a hydrogen atom, halogen atom or group chosen among (C-C)alkyl group, hydroxyl group, &#x2014;COORgroup, &#x2014;NOgroup, &#x2014;NRRgroup, morpholinyl or morpholino group, N-methylpiperazinyl group, (C-C)fluoroalkyl group, (C-C)alkoxy group and &#x2014;CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C.

Compounds useful for treating diseases caused by retroviruses

The present invention relates to compound (I) for use as an agent for preventing, inhibiting or treating AIDS, Rrepresents a hydrogen atom, a (C-C)alkyl group or a (C-C)cycloalkyl group; Ris a hydrogen atom or a chlorine atom, and Ris a hydrogen atom or a (C-C)alkyl group or anyone of its pharmaceutically acceptable salts.

Compounds useful for treating AIDS

Growing community of inventors

Le Cres, France

Noëlie Campos