The Boots Company Plc

Norman William Bristow

Bernard John Armitage

Bernard Vincent Heathcote

Stewart Sanders Adams

Kenneth J Nichol

Malcolm F Sim

Stuart Sanders Adams

Peter E Macey

Therapeutic activity, and in particular the ability to induce diuresis or saluresis, has been discovered in 4-hydroxy- or 4-mercapto-2-aryl-1,2-dihydrophthalazine-1-acetic acids, the tautomers of these namely 4-oxo or thio-2-aryl-1,2-tetrahydrophthalazine-1-acetic acids, and in the ester and alcohol derivatives of the acids, and in the acyl derivatives of the 4-hydroxy or mercapto compounds and in the 3-alkyl derivatives of the 4-oxo or thio compounds. Therapeutic compositions and methods using the compounds are described, as also are novel compounds.

Therapeutic agents

N-alkyl-N-9-xanthenylurea and substituted derivatives thereof useful in the treatment of peptic ulcer.

Xanthen derivatives such as N,N'-dimethyl-N-9-xanthenylurea and the like

4-(9-Xanthenyl)semicarbazide and thiosemicarbazide, 4-(9-thiaxanthenyl)semicarbazide and thiosemicarbazide, and derivatives of these compounds, useful as anti-secretory agents.

Xanthenyl semicarbazides

4-(9-Xanthenyl)semicarbazide and thiosemicarbazide, 4-(9-thiazanthenyl)semicarbazide and thiosemicarbazide, and derivatives of these compounds, useful as antisecretory agents.

Growing community of inventors

Nottingham, United Kingdom

Norman William Bristow