The General Hospital Corporation

Medispectra, Incorporated

Norman S Nishioka

Guillermo J Tearney

Brett Eugene Bouma

Milen Stefanov Shishkov

Benjamin J Vakoc

Robert Carruth

Michalina Gora

Kevin Gallagher

Moon Gu Lee

Nima Tabatabaei

Jenny Sauk

Kevin Schomacker

Dongkyun Kang

Alex R Zelenchuk

Yacov Domankevitz

Kevin T Schomacker

Dongyun Kang

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

An exemplary apparatus for obtaining data for at least one portion within at least one luminal or hollow sample can be provided. For example, the apparatus can include a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the portion(s). The apparatus can also include a wavelength dispersive second arrangement, which can be configured to disperse the electromagnetic radiation(s). A housing can be provided with a shape of a pill, and enclosing the first and second arrangements.

Apparatus, device and method for capsule microscopy

A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, about 403 nm, about 414 nm, and about 431 nm. The intensities of the 403 nm and 414 mn radiation are normalized using the 431 nm intensity. A score is determined using the ratios in a linear discriminant analysis (LDA). The tissue under examination is resected or not, based on the outcome of the LDA.

Colonic polyp discrimination by tissue fluorescence and fiberoptic probe

An endoscopic imaging system for viewing an object within a patient's body cavity includes: an endoscope for viewing an image of the object, the endoscope comprising a distal end, an instrument channel extending therethrough, and a lens at the distal end adjacent the instrument channel; and an elongate probe configured to be inserted through the instrument channel and contact the object, the probe comprising a plurality of unevenly spaced graduations along its length, each graduation indicating a size factor used to scale the image produced by the endoscope. The invention also relates to a method of determining the size of an object in a patient's body cavity including the steps of: generating an image of the object using an instrument; extending a probe having a series of unevenly spaced graduations from the instrument to the object; identifying the graduation on the probe visible in the image nearest to the instrument; and scaling the image viewed by the endoscope by a size factor corresponding to the identified graduation.

Apparatus and method for determining the size of an object during

An integrated optical biopsy forceps device and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws pivotally mounted at the distal end of the catheter body and controlled by control wires extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.

Optical biopsy forceps and method of diagnosing tissue

A method and device for first irradiating a region of tissue with a radiation source, and then incising the region with a mechanical cutting instrument (e.g., a scalpel). Irradiation allows for effective heating of the tissue, which results in blood vessel contraction or coagulation of the blood before the actual incision is made; once the tissue is incised, the resulting flow of blood is low.

Laser surgical devices

Growing community of inventors

Wayland, MA, United States of America

Norman S Nishioka