Piramal Imaging Sa

Technische Universitat Munchen

Norman Koglin

Heribert Schmitt-Willich

Matthias Friebe

Horst Kessler

Keith Graham

Mathias Berndt

Lutz Lehmann

Ludger Dinkelborg

Niels Böhnke

Andre Müller

Martina Anton

Oliver Demmer

Hans Jürgen Wester

Matthias Berndt

Markus Schwaiger

Burkhardt Laufer

What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.

[F-18]-labelled L-glutamic acid and L-glutamine derivatives (I), their use and processes for their preparation

This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled withF orF, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.

Homoglutamic acid derivatives

Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as ICin the presence ofI-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N-methyl derivative of a basic amino acid.

Cancer imaging and treatment

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Berlin, Germany

Norman Koglin