William H. Rorer, Inc.

Norman J Santora

George H Douglas

George W Nuss, Jr

Julius Diamond

Henry F Campbell

This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.

Method of treatment

Compositions for inhibiting cellular proliferation in mammals containing as the active ingredient N-benzylideneaniline and its derivatives, and the method therefor.

Compositions and method of treatment

This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of .alpha.-phenyl-N-phenylnitrone and derivatives thereof.

This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of a benzylideneaniline derivative, and the compositions therefore.

Benzylideneaniline derivatives

Relief of inflammation and associated pain and fever by the topical administration of .alpha.-phenyl-N-phenylnitrone and its derivatives.

Method of treating inflammation

Compositions for treating radiation induced erythemas and for protecting the human skin against the harmful effects of sunlight, containing as the active ingredient N-benzylideneaniline and its derivatives.

Sunscreen and erythema treating with N-benzylidene anilenes

This invention describes a method of treating inflammation in warmblooded animals by topically administering an effective amount of .alpha.-phenyl-N-phenylnitrone and derivatives thereof.

This invention describes a method of treating inflammation in warmblooded animals by topically administering an effective amount of benzylamine and its derivatives.

Method of topically treating inflammation

Process for preparing ethynylbenzene compounds by the dehalogenation of .beta.,.beta.,.alpha.-trichlorophenylethane compounds is described.

Preparation of ethynylbenzenes

Novel .alpha.-halo-p-cycloalkylphenylacetic acids and their derivatives have been prepared. Compounds of this invention possess useful anti-inflammatory, analgesic and antipyretic properties.

Phenylacetic acids

Novel p-cycloalkylphenylacetic acids which are substituted in .alpha.-position by a carbamylthio, loweralkylcarbamylthio, or diloweralkylcarbamylthio group, and their salts have been prepared. They possess useful antiinflammatory, analgesic, and antipyretic properties.

Certain substituted .alpha.-halo and .alpha.-mercaptophenylacetic acids and substituted phenylacetic acids having in .alpha.-position a sulfur-containing group, a cyano group, or an amino group, their substantially non-toxic esters, salts, and acid amides as well as 5-phenyl substituted 2-imino-4-oxothiazolidines and 5-phenyl substituted 2,4-dioxothiazolidines have a high anti-inflammatory, analgesic, and antipyretic activity, low toxicity, and/or a favorable therapeutic index with minor or no side-effects. Preferred compounds of this invention are .alpha.,m-dichloro-p-cyclohexylphenylacetic acids and its esters and salts.

D-aminophenylacetic acid compounds and derivatives

Novel process for preparing ethynylbenzene compounds by the dehalogenation of .beta.,.beta.,.alpha.-trichlorophenylethane compounds is described. Novel intermediates are also disclosed.

Growing community of inventors

Roslyn, PA, United States of America

Norman J Santora