Syntex (u.s.a.) Inc.

Norman H Dyson

John O Gardner

Denis John Kertesz

Anthony Prince

John C Rohloff

This invention provides an improved process for the preparation of compounds of formula (I): ##STR1## wherein: n is 0, 1 or 2;

Process for preparing 1,3-dioxolane derivatives

The invention provides a process for preparing single enantiomers of compounds represented by the formula: ##STR1## and chiral acid addition salts thereof; wherein: X and Y are independently hydrogen; lower alkyl; lower alkoxy; or halo; or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy; which includes reduction of a compound represented by the formula: ##STR2## to give a mixture of stereoisomers represented by the formula: ##STR3## wherein each wavy line independently represents a bond in either the .alpha. or .beta. position;

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Palo Alto, CA, United States of America

Norman H Dyson