The University of North Carolina at Chapel Hill

University of Texas System

The General Hospital Corporation

The Brigham and Women's Hospital, Inc.

Dana-farber-cancer Institute Inc.

G1 Therapeutics, Inc.

Norman E Sharpless

Patrick Joseph Roberts

Kwok-kin Wong

Jay Copeland Strum

Pasi Antero Janne

John Emerson Bisi

Bruce E Johnson

Nabeel Bardeesy

Diego H Castrillon

Benjamin D Humphreys

Hongbin Ji

Kwok-Kin Wong

Soren Johnson

Krishnamurthy Janakiraman

Yan Liu

Derek P DiRocco

The present invention provides methods of detecting cancer using biomarkers.

Methods of diagnosing and prognosing lung cancer

The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.

Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6

The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.

Cyclin dependent kinase inhibitors and methods of use

The presently disclosed subject matter provides methods for determining the molecular age of a tissue. Also provided are methods for employing a molecular age that has been determined for a tissue for assessing the appropriateness of various therapeutic applications for the tissue or a subject comprising the tissue.

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Growing community of inventors

Chapel Hill, NC, United States of America

Norman E Sharpless