University of Washington

Bloodworks

Puget Sound Blood Center

Norman David Brault, Jr

Shaoyi Jiang

Daniel M Ratner

Jill Marie Johnsen

James T Kirk

José A López

Hong Xue

Yuting Li

Harihara Subramanian Sundaram

Chun-Jen Huang

Qiuming Yu

Changlu Gao

Guozhu Li

Jose A Lopez

Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

Photonic pathogen detection

Photonic blood typing

Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

Hierarchical films having ultra low fouling and high recognition element loading properties

Zwitterionic polymers having adhesive groups, methods for making the polymers, surfaces having the polymers grafted thereto and grafted therefrom, and methods for making and using the polymer-modified surfaces.

Zwitterionic polymers having biomimetic adhesive linkages

Growing community of inventors

Seattle, WA, United States of America

Norman David Brault, Jr